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COVID-19 pandemic has affected our lives in all aspects. Unfortunately, there is no reliable treatment or vaccine for SARS-CoV-2 right now. Photobiomodulation (PBM) is a photon therapy based on PBM which uses a light sourcing in the visible and near-infrared spectrum. It has general effects like metabolic, analgesic, anti-inflammatory and immunomodulatory effects. The most important method for COVID-19 management are oxygenation and faster rehabilitation of the damaged tissue, antiviral effects and finally controlling the cytokine storm by reducing inflammatory agents. Photobiomodulation may be used as an adjuvant therapy or even an alternative therapy for all these mechanisms without side effects and drug interactions. We can increase these effects by combining this method with another method known as antimicrobial photodynamic therapy, possibly. Antimicrobial photodynamic therapy (aPDT) has been investigated as a novel way of inhibiting bacterial, viral and fungal infections. Studies indicate that PBM and aPDT could be useful in many viral and bacterial pulmonary complications like Influenza, SARS-CoV, and MERS. In conclusion COVID-19 disease is very unknown, and scientists in any area must manage the challenge, in any way possible. According to mechanisms mentioned earlier, we are referring to the capabilities of photobiomodulation and photodynamic therapy. The best use is a combination of both methods. Present treatments are focused on virus removal, tissue oxygenation, and reduction of cytokine storm. In combination with these two methods, we can achieve these goals with minimal interference with pharmaceutical methods and battle this disease with biophysical agents.
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