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The early diagnosis of myocardial infarction can significantly improve the survival rate in clinical medicine, therefore the high sensitivity detection of myocardial infarction biomarkers, such as creatine kinase (CK), lactate dehydrogenase (LDH) and cardiac troponin (cTn), is very important. In this work, a thin-wall microtubule whispering gallery modes (WGM) cavity biosensor to detect myocardial infarction marker has been achieved. The thin-wall microtubule WGM cavity is simply fabricated by tapering the silica capillary with oxyhydrogen flame. Using the self-polymerization effect of dopamine, the antibody is modified on the inner wall of the microtubule cavity to achieve specific capture of the cTnI-TnC complex protein. Moreover, by introducing the WGM microtubule cavity into the erbium-doped fiber laser cavity, the lasing wavelength can be utilized for the label-free detection of the myocardial infarction biomarker. The proposed microtubule cavity biosensor has advantages of inherent microfluidic channel, label-free detection and low detection limit, making itself a potential sensing platform in early diagnosis of heart disease.
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