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13 March 2024 Optogenetic stimulation for spatially precise stimulation of cochlear neurons
Ajmal Abdul Azees, Alex Thomson, Elise A. Ajay, Andrew K. Wise, Patrick Ruther, David Garrett, Anita Quigley, James B. Fallon, Rachael T. Richardson
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Proceedings Volume 12829, Optogenetics and Optical Manipulation 2024; 1282908 (2024) https://doi.org/10.1117/12.3007307
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
The cochlear implant uses electrical stimulation to activate spiral ganglion neurons to restore hearing. Despite its efficiency, electrical stimulation activates a broad region of the cochlea, thereby reducing cochlear implant performance. Optogenetic stimulation, which uses light to stimulate neurons, has the potential for precise neural activation. In this study, we compared the spread of activation and channel interaction arising from multi-channel electrical or optogenetic stimulation in the mouse cochlea. Our findings revealed that optogenetic stimulation resulted in a 2-fold narrower spread of activation. Also, optogenetics stimulation resulted in significantly lower channel interaction with adjacent channels and had a 13-fold less relative influence on threshold compared to simultaneous electrical stimulation (P<0.05), demonstrating the potential advantages of optogenetic stimulation in cochlear implant technology.
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Ajmal Abdul Azees, Alex Thomson, Elise A. Ajay, Andrew K. Wise, Patrick Ruther, David Garrett, Anita Quigley, James B. Fallon, and Rachael T. Richardson "Optogenetic stimulation for spatially precise stimulation of cochlear neurons", Proc. SPIE 12829, Optogenetics and Optical Manipulation 2024, 1282908 (13 March 2024); https://doi.org/10.1117/12.3007307
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KEYWORDS
Cochlea
Optogenetics
Neurons
Electrodes
Acoustics
Light emitting diodes
Platinum
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