From hours to seconds: towards 100x faster quantitative phase imaging via differentiable microscopy (Conference Presentation)

Udith Haputhanthri; Kithmini Herath; Ramith Hettiarachchi; Hasindu Kariyawasam; Azeem Ahmad; Balpreet S. Ahluwalia; Chamira U. S. Edussooriya; Dushan N. Wadduwage

doi:10.1117/12.2651582

16 March 2023 From hours to seconds: towards 100x faster quantitative phase imaging via differentiable microscopy (Conference Presentation)

Udith Haputhanthri, Kithmini Herath, Ramith Hettiarachchi, Hasindu Kariyawasam, Azeem Ahmad, Balpreet S. Ahluwalia, Chamira U. S. Edussooriya, Dushan N. Wadduwage

Author Affiliations +

Proceedings Volume PC12389, Quantitative Phase Imaging IX; PC1238909 (2023) https://doi.org/10.1117/12.2651582
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

With applications ranging from metabolomics to histopathology, quantitative phase microscopy (QPM) is a powerful label-free imaging modality. However, the speed of current QPM systems is limited by electronic hardware. To improve throughput further, here we propose differentiable optical-electronic quantitative phase microscopy (∂μ) that acquires images in a compressed form such that more information can be transferred beyond the electronic hardware bottleneck. The proposed microscopy uses optical feature extractors as image compressors. The resultant intensity distribution is then decompressed into QPM images by a reconstruction network. By optimizing optical-electronic parameters in an end-to-end manner, our method can improve the QPI throughput from Hours to Seconds (more than an order of magnitude).

Conference Presentation

Citation Download Citation

Udith Haputhanthri, Kithmini Herath, Ramith Hettiarachchi, Hasindu Kariyawasam, Azeem Ahmad, Balpreet S. Ahluwalia, Chamira U. S. Edussooriya, and Dushan N. Wadduwage "From hours to seconds: towards 100x faster quantitative phase imaging via differentiable microscopy (Conference Presentation)", Proc. SPIE PC12389, Quantitative Phase Imaging IX, PC1238909 (16 March 2023); https://doi.org/10.1117/12.2651582

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