Dr. Xiangkai Meng Profile

Dr. Xiangkai Meng

at Changchun Univ of Science and Technology

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Author

Publications (6)

Proceedings Article | 18 March 2021 Paper

Design of integrated droplet digital PCR gene chip

Xiangkai Meng, Guangyong Jin, Yuanhua Yu, Jian Li, Xue Tao

Proceedings Volume 11780, 1178012 (2021) https://doi.org/10.1117/12.2590032

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Proceedings Article | 26 January 2021 Paper

Study on autofluorescence characteristics of micro droplet digital PCR chip

Xiangkai Meng, Guangyong Jin, Yuan Si, Xue Tao

Proceedings Volume 11767, 1176706 (2021) https://doi.org/10.1117/12.2592171

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Proceedings Article | 4 December 2020 Paper

Research on diagnostic system integrated nucleic acid extraction and detection

Xiangkai Meng, Guangyong Jin, Zhe Wang, Ping Gong, Luyang Duanmu

Proceedings Volume 11617, 1161710 (2020) https://doi.org/10.1117/12.2584970

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Proceedings Article | 18 December 2019 Paper

An optical machine structure design of a kind of gene biochip imaging system

Zhe Wang, Yuanhua Yu, Qimeng Chen, Xiangkai Meng, Ziqi Liu

Proceedings Volume 11338, 1133808 (2019) https://doi.org/10.1117/12.2540472

KEYWORDS: Imaging systems, Image processing, Light sources, Structural design, Biological research

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Gene biochip imaging and scanning technology is a more advanced gene diagnosis technology after fluorescence quantitative PCR technology, second-generation sequencing technology and digital PCR technology. Due to the great influence of fluorescence microscopy system, the imaging and scanning technology of gene biochip with high imaging efficiency and accuracy has become a hot topic widely concerned by scholars. In this paper, two-channel laser was used as the excitation light source of the biochip, and the fluorescence imaging system of the switchable fluorescence filter was designed to realize the detection of FAM and HEX biological fluorescence signals; According to the working principle of the gene biochip imager, the finite element analysis method is used to analyze the thermal structure of the optical system, and the internal structural parameters of the optical system are optimized according to the simulation results. According to the optimization result, the illumination time of each object pixel is controlled to utilize the fluorescence information more efficiently, and the fluorescent bleaching effect is reduced without sacrificing the image quality, and the PCR amplification oil droplet quantitative reading and display is performed in real time. The gene biochip imaging system proposed in this paper can be used to image, obtain, read, process and display the detected chip with a resolution of 10 m/ pixel, a minimum detection limit of < 10 fluorescent molecules/square micron, and a sample detection repeatability of < 10%.The results show that the gene biological chip imaging system designed by this research has the advantages of low noise, low cost and fast scanning speed, and provides a theoretical basis for precision medical fields such as early diagnosis and cure evaluation of clinical tumors. The results show that the gene biochip imaging system designed by this research has the advantages of low noise, low cost and fast scanning speed, and provides a theoretical basis for precision medical fields such as early diagnosis and cure evaluation of clinical tumors.

Proceedings Article | 20 November 2014 Paper

Research on the intelligent control simulation target with IR imaging target for hardware-in-the-loop simulation test

Key-an Dong, Ye Gu, Yan An, Xiang-kai Meng, Yan Lou, Ya-lin Zhang, Juntong Zhan, Yan-song Song, Yan Dong, Shou-feng Tong

Proceedings Volume 9300, 93002D (2014) https://doi.org/10.1117/12.2073141

KEYWORDS: Infrared imaging, Infrared radiation, Thermography, Telecommunications, Control systems, Optical simulations, Target detection, Spatial resolution, Infrared detectors, Forward looking infrared

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Proceedings Article | 20 November 2014 Paper

Development of the infrared target simulation system

Xiangkai Meng, Shoufeng Tong, Yan Dong, Yansong Song, Keyan Dong

Proceedings Volume 9300, 930028 (2014) https://doi.org/10.1117/12.2073108

KEYWORDS: Infrared radiation, Infrared imaging, Thermography, Control systems, Infrared technology, Convection, Resistors, Infrared systems engineering, Weapons, Optical simulations

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