Dr Andrey Dunaev received his diploma in Instrumental Engineering (MSc) and diploma in Management (MSc) at Orel State Technical University (now - Orel State University named after I.S. Turgenev), Orel, Russia, in 1999. In December 2002 he was awarded a PhD degree for his work on Biomedical Engineering “Method of control of the absorbed radiation power in epidermis during low-level laser therapy”.
His research interests include the development of multimodal optical non-invasive diagnostics (based on laser Doppler flowmetry, tissue reflectance oximetry, fluorescence spectroscopy and so on).
Topics of research:
- methods and devices for diagnostics the functional state of microcirculatory-tissue systems of human body;
- methodological and instrumentation provision of multimodal optical diagnostics for biomedical clinical applications (for functional diagnostics, mini-invasive surgery, endocrinology, dermatology etc.);
- metrological support of multimodal optical systems.
Since 2005 he was associate professor (docent) of Department “Instrument Engineering, Metrology and Certification” at State University ESPC (now - Orel State University named after I.S. Turgenev), since 2021 - Professor. He was teaching lectures on Optoelectronic Devices in Diagnostics, Therapy and Surgery; Fundamentals of Biophotonics; Tomographic Methods in Clinical Practice; Fundamentals of Medical Biophotonics etc.
Since 2010 was a chief executive Scientific-Educational Center “Biomedical Engineering”. At 2011-2013 years worked as Postdoctoral Researcher at the University of Dundee (UK). Since 2017 is a Leading Researcher at Research & Development Center of Biomedical Photonics. Doctor of Technical Science in Biomedical Engineering (thesis on “Methods and tools for multimodal optical diagnostics of human microcirculatory-tissue systems”). Honorary Worker of Science and High Technologies of the Russian Federation (2022).
His research interests include the development of multimodal optical non-invasive diagnostics (based on laser Doppler flowmetry, tissue reflectance oximetry, fluorescence spectroscopy and so on).
Topics of research:
- methods and devices for diagnostics the functional state of microcirculatory-tissue systems of human body;
- methodological and instrumentation provision of multimodal optical diagnostics for biomedical clinical applications (for functional diagnostics, mini-invasive surgery, endocrinology, dermatology etc.);
- metrological support of multimodal optical systems.
Since 2005 he was associate professor (docent) of Department “Instrument Engineering, Metrology and Certification” at State University ESPC (now - Orel State University named after I.S. Turgenev), since 2021 - Professor. He was teaching lectures on Optoelectronic Devices in Diagnostics, Therapy and Surgery; Fundamentals of Biophotonics; Tomographic Methods in Clinical Practice; Fundamentals of Medical Biophotonics etc.
Since 2010 was a chief executive Scientific-Educational Center “Biomedical Engineering”. At 2011-2013 years worked as Postdoctoral Researcher at the University of Dundee (UK). Since 2017 is a Leading Researcher at Research & Development Center of Biomedical Photonics. Doctor of Technical Science in Biomedical Engineering (thesis on “Methods and tools for multimodal optical diagnostics of human microcirculatory-tissue systems”). Honorary Worker of Science and High Technologies of the Russian Federation (2022).
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In this work, using a model of pancreatic beta cells (RINm5F), the effect of photosensitizer-free laser-induced singlet oxygen (SO) on the bioenergetics of this type of cells was studied. It was found that laser exposure affects a number of parameters characterizing the bioenergetics of cells: mitochondrial membrane potential, NADH, FAD and ATP levels. The totality of the results obtained may indicate the potential possibility of using laser-induced SO in the regulation of beta cell functions.
LDF signals recorded at the site of psoriatic lesions of the tissue as well as in the intact tissue at a distance of 1-2 cm from the affected area were analysed. LDF signals were postprocessed by continuous wavelet transform using the Morlet wavelet.
Higher baseline perfusion was observed in both pathological groups in comparison to controls. Differences in the spectral properties between the groups studied were revealed. The results obtained demonstrated that spectral properties of the LDF signal collected in basal conditions may be the signature of microvasculature functional state.
Conducting a series of experimental studies allowed to trace the relationship of recorded signals of microcirculation of blood flow and lymph flow, as well as to study their oscillation nature by using wavelet analysis.
A diagnostic method was developed for assessing the functional state of the peripheral vessels of fingers, based on carrying out occlusion test in a thermally stabilized environment, with simultaneous recording of signals of laser Doppler flowmetry and skin thermometry. To verify the diagnostic value of the proposed method, a series of experiments were carried out on 41 rheumatological patients: 5 male and 36 females (average age 56.0±12.2 years). The most common diagnoses in the patient group were rheumatoid arthritis, arthrosis, gout and systemic lupus erythematosus. The laser analyser of blood microcirculation “LAKK-02” (SPE “LAZMA” Ltd, Russia) and a custom developed multi-channel thermometry device for low inertia thermometry were used for experimental measurements. The measurements of cutaneous temperature and the index of microcirculation were performed on the distal phalanx of the third finger of the right hand. Occlusion tests were performed with water baths at 25 and 42 °C and a tonometer cuff with a pressure of 200-220 mmHg for 3 min on the upper arm.
The results of experimental studies are presented and interpreted. These data indicate a violation of the blood supply regulation in the form of a pronounced tendency towards microvascular vasoconstriction in the fingers. Thus, the response displaying a tendency toward angiospasm among patients in the rheumatological diseases profile group was observed mainly in the most severe cases (49 % of this group). The prospects of the developed diagnostic method of microcirculatory disorders in rheumatic diseases are evaluated. Thus, cutaneous blood microcirculation and temperature measurements performed together can help in diagnosis of the functional state of peripheral vessels both in a healthy state and when expressing pathology.
We proposed one possible implementation of the Monte Carlo method for the theoretical analysis of the effect of blood on the fluorescence signals. The simulation is constructed as a four-layer skin optical model based on the known optical parameters of the skin with different levels of blood supply. With the help of the simulation, we demonstrate how the level of blood supply can affect the appearance of the fluorescence spectra.
In addition, to describe the properties of biological tissue, which may affect the fluorescence spectra, we turned to the method of diffuse reflectance spectroscopy (DRS). Using the spectral data provided by the DRS, the tissue attenuation effect can be extracted and used to correct the fluorescence spectra.
A novel excitation-emission wavelength model to facilitate the diagnosis of urinary bladder diseases
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