Dr. Guoqiang Chen Profile

Dr. Guoqiang Chen

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Proceedings Article | 15 December 2022 Paper

Reliability investigation of Mueller matrix imaging polarimeter in identifying cervical intraepithelial neoplasia

Wen’ai Wang, Jiabei Li, Guoqiang Chen, Yanqiu Li

Proceedings Volume 12478, 1247814 (2022) https://doi.org/10.1117/12.2652153

KEYWORDS: Tissues, Polarization, Reliability, Diagnostics, Scattering, Polarimetry, Imaging systems, Cervix

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As a serious threat to women's lives and health, cervical cancer ranks second only to breast cancer in the incidence rate and mortality rate among female tumors in the world. Early diagnosis and treatment could be conducive to improving patients' survival activity index. Mueller matrix imaging polarimeter can detect the full polarization characteristics of a sample, and has shown an optimistic prospect in diagnosing various diseases. By analyzing the polarization parameters related to scattering and optical anisotropic properties of samples, detailed microstructure information can be obtained. In this paper, an in-house high-precision Mueller matrix imaging polarimeter with an objective lens NA of 0.40 was used to detect dewaxed, unstained, and unsealed cervical pathological sections, including 325 cases of CIN 1, CIN 2, CIN 3, and normal cervical tissues respectively. The Mueller matrix polar decomposition parameters, including depolarization, retardance, and diattenuation of different degrees of cervical tissues are derived. The relationship between the structure and polarization characteristics of different lesions was analyzed. Furthermore, by utilizing the receiver operating characteristic (ROC) curves, the optimal diagnostic threshold, specificity and sensitivity are calculated. Simultaneously, the diagnostic reliability of the MMIP with different polarization parameters among normal, CIN 1, CIN-2, and CIN-3 cervical tissue sections is demonstrated at about 82.8%-99.8%. This study proves the reliability and effectiveness of the self-developed MMIP in the detection of cervical tissue sections and is expected to become a powerful tool to assist doctors in pathological diagnosis.

Proceedings Article | 13 December 2021 Paper

Contrast enhancement of polarization-sensitive optical coherence tomography skin images

Jipeng Ding, Guoqiang Chen, Yuanhe Li, Yanqiu Li

Proceedings Volume 12075, 1207506 (2021) https://doi.org/10.1117/12.2605255

KEYWORDS: Optical coherence tomography, Image contrast enhancement

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Optical coherence tomography (OCT) is a new imaging technique for observing biological tissue structure. Polarization-sensitive optical coherence tomography (PS-OCT) is a functional extension of OCT, which uses polarized light to probe the sample and extract the polarization properties by detecting the change of the polarization state. In the practical application environment, the optical characteristics of biological samples and the instability of the system will reduce the contrast of the image. Traditional contrast enhancement methods are mostly based on histogram equalization and histogram matching to improve the global quality, which causes the loss of some details of the image and the excessive enhancement of noise. To solve this problem, a local contrast enhancement method is proposed in this paper. The target region and the background region are processed differently by threshold segmentation to enhance the contrast of the signal region and restrain the excessive enhancement of the background noise at the same time. The experimental results showed that this method can enhance the contrast of PS-OCT images and improve the image quality effectively. We believe that this method may play an important role in the application of PS-OCT technology in clinical research.

Proceedings Article | 10 October 2020 Poster + Paper

Design of measurement and control system for dual incidence polarization high-speed Jones matrix optical coherence tomography

Jipeng Ding, Yanqiu Li, Guoqiang Chen, Meng Zheng

Proceedings Volume 11550, 115501B (2020) https://doi.org/10.1117/12.2575275

KEYWORDS: Polarization, Tissues, Optical coherence tomography, 3D image processing, Control systems, Biological research, Imaging systems, Diagnostics, Birefringence, Scanners

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In order to analyze the polarization properties of biological tissues, we constructed a high-speed three-dimensional swept -source polarization sensitive optical coherence tomography (PS-OCT) imaging system with the axial scanning rate up to 200KHz. For automatically detecting and analyzing the polarization properties of peristaltic living tissues in real-time, an advanced measurement and control system is designed using laboratory virtual instrument technology. Based on the producer-consumer pattern, the system mainly includes the sample arm scanning galvanometer module, the interference data acquisition module, the interference data real-time processing and display module, the interference data storage module. Each module not only independently completes specific sub-functions but also interacts with others. In-vivo human finger and in-vitro pork tissue were imaged using the system. The experimental results show that the home-made system obtains 78 cross sectional B-scans per second, and can display two-dimensional OCT images and acquire threedimensional OCT data all in real-time. This robust measurement and control system has the characteristics of short design cycle, high flexibility and real-time monitoring, will significantly promote the development of PS-OCT in clinical applications.

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