Prof. Lev T. Perelman Profile

Prof. Lev T. Perelman

Professor & Director at Harvard University & BIDMC

SPIE Involvement:

Author

Publications (24)

Proceedings Article | 13 March 2024 Presentation

Multispectral functional imaging of organoids and 3D cell cultures

Lev Perelman

Proceedings Volume PC12862, PC128620M (2024) https://doi.org/10.1117/12.3011297

KEYWORDS: Tissues, Multispectral imaging, Functional imaging, 3D image processing, Stem cells, Raman spectroscopy, Confocal microscopy, Biological samples, Biological research, Vibration

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Proceedings Article | 12 March 2024 Presentation + Paper

Endoscopic light scattering spectroscopy for in vivo detection of pre-cancer in bile duct

Le Qiu, Douglas Pleskow, Mandeep Sawhney, Paul Upputuri, Tyler Berzin, Mark Coughlan, Umar Khan, Xuejun Zhang, Jonah Cohen, Yuri Zakharov, Lei Zhang, Lev Perelman

Proceedings Volume 12856, 1285603 (2024) https://doi.org/10.1117/12.2692402

KEYWORDS: Cancer detection, Diagnostics, Scattering, In vivo imaging, Backscatter, Tissues, Spectroscopy, Light scattering, Endoscopy, Cancer

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Proceedings Article | 9 August 2023 Paper

C-CLASS microscopy allows the detection of nanoscale changes in chromatin structure

Mark Coughlan, Giuseppe Pettinato, Maria Glyavina, Xuejun Zhang, Liming Chen, Umar Khan, Paul Upputuri, Yuri Zakharov, Lei Zhang, Le Qiu, Lev Perelman

Proceedings Volume 12630, 126300U (2023) https://doi.org/10.1117/12.2667044

KEYWORDS: Light scattering, Spectroscopy, Confocal microscopy, Imaging spectroscopy

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Proceedings Article | 3 March 2022 Paper

A portable light scattering system for detecting expelled droplets to assess Covid-19 transmission risk

Mark Coughlan, Mandeep Sawhney, Douglas Pleskow, Tyler Berzin, Umar Khan, Maria Glyavina, Xuejun Zhang, Liming Chen, Paul Upputuri, Conor Sheil, Mohammad Bilal, Joseph Feuerstein, Andy Silva-Santisteban, Yuri Zakharov, Edward Vitkin, Irving Itzkan, Lei Zhang, Le Qiu, Lev Perelman

Proceedings Volume 11974, 1197406 (2022) https://doi.org/10.1117/12.2608902

KEYWORDS: Scattering, Light scattering, Particles, Cameras, Visualization, Sensors, Imaging systems, Endoscopy, Computer aided design, Aerosols

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Proceedings Article | 3 March 2022 Presentation

Spectroscopic label-free light scattering microscopy of chromatin organization and dynamics in live cells

Mark Coughlan, Maria Glyavina, Giuseppe Pettinato, Yuri Zakharov, Xuejun Zhang, Umar Khan, Liming Chen, Paul Upputuri, Edward Vitkin, Irving Itzkan, Lei Zhang, Le Qiu, Lev Perelman

Proceedings Volume PC11974, PC1197408 (2022) https://doi.org/10.1117/12.2608948

KEYWORDS: Light scattering, Spectroscopy, Microscopy, Confocal microscopy, Genomics, Diffraction, Structural dynamics, Scattering, Natural surfaces, Nanotechnology

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Proceedings Article | 5 March 2021 Presentation

Imaging and spectroscopy with scattered light from the tissue to chromatin scale

Mark Coughlan, Maria Glyavina, Xuejun Zhang, Umar Khan, Yuri Zakharov, Edward Vitkin, Lei Zhang, Irving Itzkan, Douglas Pleskow, Le Qiu, Lev Perelman

Proceedings Volume 11622, 116220D (2021) https://doi.org/10.1117/12.2590876

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Proceedings Article | 24 January 2011 Paper

Differential spectral imaging with gold nanorod light scattering labels

Le Qiu, Edward Vitkin, Lianyu Guo, Eugene Hanlon, Irving Itzkan, Lev Perelman

Proceedings Volume 7945, 79452E (2011) https://doi.org/10.1117/12.874240

KEYWORDS: Gold, Scattering, Quantum dots, Luminescence, Light scattering, Tissues, Imaging spectroscopy, Biomedical optics, Scatter measurement, Nanorods

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Proceedings Article | 2 May 2008 Paper

Confocal light scattering and absorption spectroscopic microscopy

Le Qiu, Edward Vitkin, Saira Salahuddin, Munir Zaman, Charlotte Andersson, Steven Freedman, Eugene Hanlon, Irving Itzkan, Lev Perelman

Proceedings Volume 6991, 69910X (2008) https://doi.org/10.1117/12.781562

KEYWORDS: Confocal microscopy, Light scattering, Microscopy, Spectroscopy, Absorption, Absorption spectroscopy, Scattering, Objectives, Refractive index, Luminescence

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Proceedings Article | 11 March 2008 Paper

Studying cell dynamics and function with CLASS microscopy

Le Qiu, Edward Vitkin, Saira Salahuddin, Bradley Turner, Sarah Keates, Mark Modell, Rama Bansil, Irving Itzkan, Eugene Hanlon, Lev Perelman

Proceedings Volume 6864, 68640T (2008) https://doi.org/10.1117/12.762251

KEYWORDS: Microscopes, Microscopy, Confocal microscopy, Light scattering, Luminescence, Particles, Spectroscopy, Beam splitters, Mirrors, Objectives

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Proceedings Article | 15 February 2007 Paper

Studying cells in vivo with confocal light absorption and scattering spectroscopy (CLASS)

Le Qiu, Hui Fang, Edward Vitkin, Munir Zaman, Charlotte Andersson, Saira Salahuddin, Lauren Kimerer, Patsy Cipolloni, Mark Modell, Steven Freedman, Irving Bigio, Irving Itzkan, Eugene Hanlon, Lev Perelman

Proceedings Volume 6446, 64460I (2007) https://doi.org/10.1117/12.699385

KEYWORDS: Light scattering, Microscopy, Confocal microscopy, Spectroscopy, Scattering, Refractive index, Absorption, Microscopes, Absorption spectroscopy, Cell death

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Proceedings Article | 7 February 2007 Paper

Analyzing cell structure and dynamics with confocal light scattering and absorption spectroscopic microscopy

Le Qiu, Edward Vitkin, Hui Fang, Munir Zaman, Charlotte Andersson, Saira Salahuddin, Mark Modell, Steven Freedman, Eugene Hanlon, Irving Itzkan, Lev Perelman

Proceedings Volume 6436, 643606 (2007) https://doi.org/10.1117/12.711694

KEYWORDS: Light scattering, Microscopy, Confocal microscopy, Scattering, Spectroscopy, Particles, Refractive index, Beam splitters, Cell death, Absorption

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Proceedings Article | 7 March 2006 Paper

Noninvasive dosimetry and monitoring of TTT using spectral imaging

G. Schuele, F. Molnar, D. Yellachich, E. Vitkin, L. Perelman, D. Palanker

Proceedings Volume 6138, 61381G (2006) https://doi.org/10.1117/12.642338

KEYWORDS: Reflectivity, Laser scattering, Imaging spectroscopy, Scattering, Spectroscopy, Visible radiation, Light scattering, Image analysis, Blood, Absorption

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SPIE Journal Paper | 1 September 2005 Open Access

Optical spectroscopy noninvasively monitors response of organelles to cellular stress

Georg Schuele, Edward Vitkin, Philip Huie, Caitlin O'Connell-Rodwell, Daniel Palanker, Lev Perelman

JBO, Vol. 10, Issue 05, 051404, (September 2005) https://doi.org/10.1117/12.10.1117/1.2075207

KEYWORDS: Scattering, Light scattering, Particles, Refractive index, Optical spectroscopy, Transmission electron microscopy, Spectroscopy, Scatter measurement, Mie scattering, Medicine

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Proceedings Article | 18 April 2005 Paper

Optical monitoring of thermal effects in the retina during laser exposure

Georg Schuele, Philip Huie, Dimitri Yellachich, Fanni Molnar, Caitlin O’Conell-Rodwell, Edward Vitkin, Lev Perelman, Daniel Palanker

Proceedings Volume 5688, (2005) https://doi.org/10.1117/12.591068

KEYWORDS: Light scattering, Scattering, Refractive index, Particles, Transmission electron microscopy, Mie scattering, Spectroscopy, Proteins, Temperature metrology, Thermography

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Proceedings Article | 13 July 2004 Paper

Noninvasive monitoring of the thermal stress in RPE using light-scattering spectroscopy

Georg Schule, Philip Huie, Alexander Vankov, Edward Vitkin, Hui Fang, Eugene Hanlon, Lev Perelman, Daniel Palanker

Proceedings Volume 5314, (2004) https://doi.org/10.1117/12.529415

KEYWORDS: Light scattering, Scattering, Spectroscopy, Temperature metrology, Laser therapeutics, Refractive index, Photodynamic therapy, Optical testing, Lamps, Laser coagulation

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Proceedings Article | 1 May 2002 Paper

Imaging and measurement of cell structure and organization with submicron accuracy using light scattering spectroscopy

Vadim Backman, Rajan Gurjar, Lev Perelman, Venkatesh Gopal, Maxim Kalashnikov, Kamran Badizadegan, Adam Wax, Irene Georgakoudi, Markus Mueller, Charles Boone, Irving Itzkan, Ramachandra Dasari, Michael Feld

Proceedings Volume 4613, (2002) https://doi.org/10.1117/12.465234

KEYWORDS: Light scattering, Tissue optics, Tissues, Scattering, Refractive index, Imaging spectroscopy, Spectroscopy, Polarization, Particles, Cancer

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Proceedings Article | 4 May 2001 Paper

Detection of early cancer and precancer with scattered light

Lev Perelman, Vadim Backman

Proceedings Volume 4241, (2001) https://doi.org/10.1117/12.431516

KEYWORDS: Light scattering, Tissues, Tissue optics, Cancer, Biopsy, Spectroscopy, Refractive index, Scattering, Diagnostics, Colon

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SPIE Journal Paper | 1 April 2000 Open Access

Feasibility of field-based light scattering spectroscopy

Changhuei Yang, Lev Perelman, Adam Wax, Ramachandra Dasari, Michael Feld

JBO, Vol. 5, Issue 02, (April 2000) https://doi.org/10.1117/12.10.1117/1.429980

KEYWORDS: Light scattering, Heterodyning, Scattering, Sensors, Mie scattering, Laser beam diagnostics, Spectroscopy, Refractive index, Interferometry, Mirrors

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SPIE Journal Paper | 1 April 2000 Open Access

Optical computed tomography in a turbid medium using early arriving photons

Kun Chen, Lev Perelman, Qingguo Zhang, Ramachandra Dasari, Michael Feld

JBO, Vol. 5, Issue 02, (April 2000) https://doi.org/10.1117/12.10.1117/1.429981

KEYWORDS: Photons, Point spread functions, Scattering, Diffusion, X-rays, Tissue optics, Reconstruction algorithms, Absorption, X-ray computed tomography, X-ray optics

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Proceedings Article | 15 July 1999 Paper

Quantitative analysis of mucosal tissues in patients using light scattering spectroscopy

Lev Perelman, George Zonios, Vadim Backman, Rajan Gurjar, Irving Itzkan, Ramachandra Dasari, Jacques Van Dam, Michael Feld

Proceedings Volume 3597, (1999) https://doi.org/10.1117/12.356844

KEYWORDS: Tissues, Scattering, Diffuse reflectance spectroscopy, Absorption, Light scattering, Refractive index, Polarization, Spectroscopy, Tissue optics, Cancer

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Proceedings Article | 30 May 1995 Paper

Optical imaging in turbid media using early arriving photons

Lev Perelman, Jun Wu, Irving Itzkan, Yang Wang, Ramachandra Dasari, Michael Feld

Proceedings Volume 2389, (1995) https://doi.org/10.1117/12.209972

KEYWORDS: Photons, Diffusion, Optical imaging, Tissue optics, Scattering, Streak cameras, Pulsed laser operation, Biological research, Radiative transfer, Light scattering

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Proceedings Article | 22 May 1995 Paper

Photomechanical basis of laser ablation of biological tissue

Lev Perelman, Douglas Albagli, Marta Dark, Charles von Rosenberg, Irving Itzkan, Michael Feld, Jonathan Schaffer

Proceedings Volume 2391, (1995) https://doi.org/10.1117/12.209898

KEYWORDS: Laser ablation, Laser tissue interaction, Tissues, Natural surfaces, Tissue optics, 3D modeling, Bone, Soft tissue optics, Cavitation, Laser scattering

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Proceedings Article | 31 January 1995 Paper

Time-resolved 3D imaging of fluorescent objects in turbid media

Jun Wu, Yang Wang, Lev Perelman, Irving Itzkan, Ramachandra Dasari, Michael Feld

Proceedings Volume 2326, (1995) https://doi.org/10.1117/12.200864

KEYWORDS: Luminescence, Photons, Raman scattering, Streak cameras, Spectroscopy, Raman spectroscopy, Time resolved spectroscopy, Picosecond phenomena, Spatial resolution, Scattering

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Proceedings Article | 17 August 1994 Paper

Physics of laser-induced stress wave propagation, cracking, and cavitation in biological tissue

Lev Perelman, Douglas Albagli, Marta Dark, Jonathan Schaffer, Charles von Rosenberg, Irving Itzkan, Michael Feld

Proceedings Volume 2134, (1994) https://doi.org/10.1117/12.182930

KEYWORDS: Laser tissue interaction, Cavitation, Wave propagation, Natural surfaces, Tissues, Physics, Pulsed laser operation, Laser ablation, Bone, Laser development

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Showing 5 of 24 publications

Conference Committee Involvement (15)

Biomedical Applications of Light Scattering XIII

28 January 2023 | San Francisco, California, United States

Biomedical Applications of Light Scattering XII

22 January 2022 | San Francisco, California, United States

Biomedical Applications of Light Scattering XI

6 March 2021 | Online Only, California, United States

Biomedical Applications of Light Scattering X

1 February 2020 | San Francisco, California, United States

Biomedical Applications of Light Scattering IX

7 February 2015 | San Francisco, California, United States

Biomedical Applications of Light Scattering VIII

1 February 2014 | San Francisco, California, United States

Biomedical Applications of Light Scattering VII

2 February 2013 | San Francisco, California, United States

Biomedical Applications of Light Scattering VI

21 January 2012 | San Francisco, California, United States

Biomedical Applications of Light Scattering V

22 January 2011 | San Francisco, California, United States

Biomedical Applications of Light Scattering IV

23 January 2010 | San Francisco, California, United States

Biomedical Applications of Light Scattering III

24 January 2009 | San Jose, California, United States

Biomedical Applications of Light Scattering II

19 January 2008 | San Jose, California, United States

Biomedical Applications of Light Scattering

20 January 2007 | San Jose, California, United States

Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII

26 January 2004 | San Jose, CA, United States

Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII

27 January 2003 | San Jose, CA, United States

Showing 5 of 15 Conference Committees

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