Dr. Marvin M. Doyley Profile

Dr. Marvin M. Doyley

Associate Professor at Univ of Rochester

SPIE Involvement:

Conference Program Committee | Editorial Board Member: Journal of Medical Imaging | Author | Editor

Publications (24)

SPIE Journal Paper | 18 November 2024 Open Access

Combined dual-channel fluorescence depth sensing of indocyanine green and protoporphyrin IX kinetics in subcutaneous murine tumors

Madhusudan Kulkarni, Matthew Reed, Xu Cao, Héctor García, Marien Ochoa, Shudong Jiang, Tayyaba Hasan, Marvin Doyley, Brian Pogue

JBO, Vol. 30, Issue S1, S13709, (November 2024) https://doi.org/10.1117/12.10.1117/1.JBO.30.S1.S13709

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SignificanceFluorescence sensing within tissue is an effective tool for tissue characterization; however, the modality and geometry of the image acquisition can alter the observed signal.AimWe introduce a novel optical fiber-based system capable of measuring two fluorescent contrast agents through 2 cm of tissue with simple passive electronic switching between the excitation light, simultaneously acquiring fluorescence and excitation data. The goal was to quantify indocyanine green (ICG) and protoporphyrin IX (PpIX) within tissue, and the sampling method was compared with wide-field surface imaging to contrast the value of deep sensing versus surface imaging.ApproachThis was achieved by choosing filters for specific wavelengths that were mutually exclusive between ICG and PpIX and coupling these filters to two separate detectors, which allows for direct swapping of the excitation and emission channels by switching the on-time of each excitation laser between 780- and 633-nm wavelengths.ResultsThis system was compared with two non-contact surface imaging systems for both ICG and PpIX, which revealed that the fluorescence depth sensing system was superior in its ability to resolve kinetics differences in deeper tissues that would normally be dominated by strong signals from skin and other surface tissues. Specifically, the system was tested using pancreatic adenocarcinoma tumors injected into murine models, which were imaged at several time points throughout tumor growth to its ∼6-mm diameter. This demonstrated the system’s capability to track longitudinal changes in ICG and PpIX kinetics that result from tumor growth and development, with larger tumors showing sluggish uptake and clearance of ICG, which was not observable with surface imaging. Similarly, PpIX was quantified, which showed slower kinetics over different time points, and was further compared with the wide-filed imager. These results were further validated through depth measurements in tissue phantoms and model-based interpretation.ConclusionThis fluorescence depth sensing system can be used to sample the interior blood flow characteristics by ICG sensing of tissue as deep as 20 mm into the tissue with sensitivity to kinetics that are superior to surface imaging and may be combined with other imaging modalities such as ultrasound to provide guided deep fluorescence measurements.

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Proceedings Article | 13 March 2024 Poster + Paper

Prototype dual-channel fluorescence/transmission optical tomography system for quantification of capillary permeability and porphyrin production

Madhusudan Kulkarni, Matthew Reed, Shudong Jiang, Xu Cao, Tayyaba Hasan, Marvin Doyley, Brian Pogue

Proceedings Volume 12825, 128250F (2024) https://doi.org/10.1117/12.3021036

KEYWORDS: Tissues, Fluorescence, Optical tomography, Prototyping, Optical transmission, Linear filtering, Data acquisition, Capillaries, Fluorescence intensity, Animals

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Fluorescence optical tomography systems have been invented to directly measure several deep tissue features. While the highly scattered nature of the signal degrades spatial resolution, this scattering process also dramatically increases the optical path length and thereby amplifies the signal sensitivity to features such as capillaries and cells, suppressing the dominance of major blood vessels. The potential for high optical contrast with centimeter-level penetration into tissue motivates sampling (i) capillary leakage with a temporal sampling of indocyanine green (ICG); (ii) mitochondrial activity with protoporphyrin IX (PpIX) intensity, and (iii) oxygen metabolism sensing with delayed fluorescence of PpIX. In this work, the single-channel prototype of an optical fiber-based tomography system was developed for these purposes. The system was comprised of two sources of laser diodes, at 633 nm and 780 nm wavelengths, two avalanche photodiode detectors, a DAQ I/O card as a control and data collection unit, and fiber cables with filter blocks, all run via LabView control. The detection fiber channels included a notch filter in each arm, at 633nm and 750nm wavelengths that act as a band stop filter for these wavelengths. Fiber cables deliver and receive light from the tissue, enabling a closed-loop passive switching system. This design has a dual-purpose channel fiber system that makes it possible to just electronically switch between sequential measurement of indocyanine green (ICG) excitation (785 nm) and protoporphyrin IX (PpIX) excitation (635 nm) without any optical component movements, while transmission of the excitation signal is implicitly measured at the opposite detector. The fluorescence-to-transmission ratio data eliminates issues of fiber coupling or tissue transmission variations. The system was validated for linearity of response in relevant biological concentration ranges for each fluorophore. Also, in vivo animal studies were carried out on a mouse to see the reliability of the system at capturing the temporal ICG kinetics. This single design of dual-channel detection is a prototype for what will be a multi-fiber tomography system that can measure the intrinsic properties of tissue coupled with ultrasound imaging.

Proceedings Article | 13 March 2024 Presentation + Paper

Variation in second-window ICG retention is independent of initial vascular permeability in experimental pancreatic adenocarcinoma tumors

Matthew Reed, Marien Ochoa, Marvin Doyley, Brian Pogue

Proceedings Volume 12825, 128250A (2024) https://doi.org/10.1117/12.3003535

KEYWORDS: Tumors, Tissues, Permeability, Biological imaging, Lymphatic system, Imaging systems, Fluorescence imaging, Capillaries, Cameras, Muscles

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SPIE Journal Paper | 13 July 2023 Open Access

Mapping estimates of vascular permeability with a clinical indocyanine green fluorescence imaging system in experimental pancreatic adenocarcinoma tumors

Matthew Reed, Marien Ochoa, Kenneth Tichauer, Ashley Weichmann, Marvin Doyley, Brian Pogue

JBO, Vol. 28, Issue 07, 076001, (July 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.7.076001

KEYWORDS: Tumors, Tissues, Imaging systems, Permeability, Capillaries, Fluorescence imaging, Muscles, Data modeling, Biological imaging, Skin

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Proceedings Article | 10 April 2023 Presentation + Paper

Distributed aberration correction in handheld ultrasound based on tomographic estimates of the speed of sound

Rehman Ali, Trevor Mitcham, Melanie Singh, Richard Bouchard, Jeremy Dahl, Marvin Doyley, Nebojsa Duric

Proceedings Volume 12470, 1247009 (2023) https://doi.org/10.1117/12.2653935

KEYWORDS: Apodization, Aberration correction, Ultrasonography, Tomography

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Proceedings Article | 7 April 2023 Poster + Paper

Reverberant magnetic resonance elastography

Irteza Enan Kabir, Diego Caban-Rivera, Juvenal Ormachea, Kevin Parker, Curtis Johnson, Marvin Doyley

Proceedings Volume 12463, 124633L (2023) https://doi.org/10.1117/12.2654305

KEYWORDS: Magnetic resonance elastography, Elastography, Tissues, Brain, Matrices, Magnetic resonance imaging, Vibration, Scanners

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SPIE Journal Paper | 1 November 2022

Separation of mainlobe and sidelobe contributions to B-mode ultrasound images based on the aperture spectrum

Rehman Ali, Trevor Mitcham, Leandra Brickson, Wentao Hu, Marvin Doyley, Deborah Rubens, Zeljko Ignjatovic, Nebojsa Duric, Jeremy Dahl

JMI, Vol. 9, Issue 06, 067001, (November 2022) https://doi.org/10.1117/12.10.1117/1.JMI.9.6.067001

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Proceedings Article | 4 April 2022 Presentation

Second-generation Dual Scan Mammoscope (DSM-2)

Emily Zheng, Huijuan Zhang, Goswami Soumya, Enan Kabir, Marvin Doyley, Jun Xia

Proceedings Volume 12036, 120360Y (2022) https://doi.org/10.1117/12.2607643

KEYWORDS: Imaging systems, Ultrasonography, Tissues, Photoacoustic spectroscopy, In vivo imaging, Elastography, Breast, X-rays, X-ray imaging, Scanners

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Proceedings Article | 19 April 2017 Presentation

Local pressure and matrix component effects on verteporfin distribution in pancreatic tumors (Conference Presentation)

Michael Nieskoski, Kayla Marra, Jason Gunn, Marvin Doyley, Kimberly Samkoe, Stephen Pereira, B. Stuart Trembly, Brian Pogue

Proceedings Volume 10047, 1004708 (2017) https://doi.org/10.1117/12.2249766

KEYWORDS: Targeting Task Performance metric, Tissues, Collagen, Therapeutics, Solids, Proteins, Tissue optics, Photodynamic therapy, Tumors, Tumor growth modeling

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SPIE Journal Paper | 4 July 2014 Open Access

Quantitative sparse array vascular elastography: the impact of tissue attenuation and modulus contrast on performance

Steven Huntzicker, Rohit Nayak, Marvin Doyley

JMI, Vol. 1, Issue 02, 027001, (July 2014) https://doi.org/10.1117/12.10.1117/1.JMI.1.2.027001

KEYWORDS: Signal attenuation, Elastography, Tissues, Arteries, Visualization, Imaging arrays, Image processing, Acoustics, Magnetic resonance imaging, Chemical elements

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Proceedings Article | 20 March 2014 Paper

Synthetic aperture elastography: a GPU based approach

Prashant Verma, Marvin Doyley

Proceedings Volume 9040, 90401A (2014) https://doi.org/10.1117/12.2046374

KEYWORDS: Elastography, Ultrasonography, Imaging systems, Image quality standards, Signal to noise ratio, Real-time computing, Image quality, Signal processing, Digital signal processing, Graphics processing units

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Proceedings Article | 29 March 2013 Paper

Strain estimation of carotid artery using virtual element based synthetic aperture imaging

Rohit Nayak, Sanghamithra Korukonda, Marvin Doyley

Proceedings Volume 8675, 86750I (2013) https://doi.org/10.1117/12.2007214

KEYWORDS: Arteries, Acoustics, Point spread functions, Transducers, Synthetic aperture imaging, Elastography, Ultrasonography, Spherical lenses, Computer simulations, Multi-element lenses

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Proceedings Article | 29 March 2013 Paper

Reconstructing the mechanical properties of coronary arteries from displacements measured with a synthetic aperture ultrasound imaging system

Steven Huntzicker, Sanghamithra Korukonda, Marvin Doyley

Proceedings Volume 8675, 867511 (2013) https://doi.org/10.1117/12.2008636

KEYWORDS: Ultrasonography, Computer simulations, Imaging systems, Tissues, Finite element methods, Arteries, Synthetic aperture radar, Magnetic resonance imaging, Chemical elements, Signal to noise ratio

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Proceedings Article | 29 March 2013 Paper

Nonlinear response of lipid-shelled microbubbles to coded excitation: implications for noninvasive atherosclerosis imaging

Himanshu Shekhar, Marvin Doyley

Proceedings Volume 8675, 867510 (2013) https://doi.org/10.1117/12.2007065

KEYWORDS: Nonlinear response, Transducers, Ultrasonography, Acoustics, Signal to noise ratio, Nonlinear optics, Visualization, Image enhancement, Scanners, Nondestructive evaluation

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Proceedings Article | 25 February 2012 Paper

High-frequency subharmonic emission with chirp-coded excitation: implications for imaging

Himanshu Shekhar, Marvin Doyley

Proceedings Volume 8320, 83200V (2012) https://doi.org/10.1117/12.911952

KEYWORDS: Ultrasonography, Transducers, Image resolution, Tissues, Spatial resolution, Visualization, Acoustics, Pathology, Preclinical imaging, Apodization

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Proceedings Article | 25 February 2012 Paper

A high frequency ultrasound aided study of kinetics of drug delivery in tumor models

Sason Torosean, Brendan Flynn, Kimberley Samkoe, Jason Gunn, Johan Axelsson, Marvin Doyley, Brian Pogue

Proceedings Volume 8320, 83200Y (2012) https://doi.org/10.1117/12.911954

KEYWORDS: Tumors, Collagen, Luminescence, Nanoparticles, Tissues, Tissue optics, Ultrasonography, Solids, In vivo imaging, Sensors

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Proceedings Article | 28 February 2009 Paper

Radial basis function strain estimator

Marvin Doyley, David Manegold, Minh Q. Phan

Proceedings Volume 7262, 72621I (2009) https://doi.org/10.1117/12.817138

KEYWORDS: Tissues, Spatial resolution, Visibility, Image filtering, Spatial filters, Elastography, Breast, Composites, Image resolution, Visualization

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Proceedings Article | 6 April 2007 Paper

Reproducibility of MRE shear modulus estimates

John Weaver, Timothy Miller, Marvin Doyley, Huifang Wang, Phillip Perrinez, Yvonne Cheung, Francis Kennedy, Keith Paulsen

Proceedings Volume 6511, 65111T (2007) https://doi.org/10.1117/12.713772

KEYWORDS: Tissues, Motion estimation, Scanners, Magnetic resonance imaging, Signal to noise ratio, Motion measurement, Magnetic resonance elastography, Phase measurement, Cancer, Medical imaging

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Proceedings Article | 6 April 2007 Paper

The effects of interstitial tissue pressure on the measured shear modulus in vivo

John Weaver, P. Perrinez, J. Bergeron, F. Kennedy, H. Wang, S. Scott Lollis, M. Doyley, P. Hoopes, K. Paulsen

Proceedings Volume 6511, 65111A (2007) https://doi.org/10.1117/12.713781

KEYWORDS: Tissues, Brain, Cancer, In vivo imaging, Magnetic resonance elastography, Atmospheric modeling, Elastography, Animal model studies, Actuators, Pathology

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Proceedings Article | 29 March 2007 Paper

A phase unwrapping method for large-motion phase data in MR elastography

Huifang Wang, John Weaver, Marvin Doyley, Francis Kennedy, Keith Paulsen

Proceedings Volume 6511, 65111S (2007) https://doi.org/10.1117/12.710073

KEYWORDS: Magnetic resonance elastography, Monte Carlo methods, Motion estimation, Elastography, Error analysis, Data centers, Wave propagation, Medical imaging, Motion analysis, Motion models

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Proceedings Article | 13 March 2006 Paper

MR elastographic methods for the evaluation of plantar fat pads: preliminary comparison of the shear modulus for shearing deformation and compressive deformation in normal subjects

John Weaver, Timothy Miller, Philip Perrinez, Marvin Doyley, Huifang Wang, Yvonne Cheung, James Wrobel, Richard Comi, Francis Kennedy, Keith Paulsen

Proceedings Volume 6143, 61430Y (2006) https://doi.org/10.1117/12.652828

KEYWORDS: Tissues, Computing systems, Motion measurement, Actuators, Magnetic resonance imaging, Anisotropy, In vivo imaging, Signal generators, Elastography, Magnetic resonance elastography

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Proceedings Article | 13 March 2006 Paper

Optimized motion estimation for MRE data with reduced motion encodes

Huifang Wang, John Weaver, Marvin Doyley, Qing Feng, Francis Kennedy, Keith Paulsen

Proceedings Volume 6143, 614325 (2006) https://doi.org/10.1117/12.650135

KEYWORDS: Magnetic resonance elastography, Motion estimation, Tissues, Computer programming, Error analysis, Computer simulations, Monte Carlo methods, Fourier transforms, Phase measurement, Data acquisition

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SPIE Journal Paper | 1 October 2003

Near-infrared breast tomography calibration with optoelastic tissue simulating phantoms

Shudong Jiang, Brian Pogue, Troy McBride, Marvin Doyley, Steven Poplack, Keith Paulsen

JEI, Vol. 12, Issue 04, (October 2003) https://doi.org/10.1117/12.10.1117/1.1587153

KEYWORDS: Calibration, Breast, Tissues, Sensors, Transceivers, Blood, Imaging systems, Absorption, Optical properties, Tomography

Proceedings Article | 16 April 1997 Paper

Visual detectability of elastic contrast in real-time ultrasound images

Naomi Miller, Jeffery Bamber, Marvin Doyley, Martin Leach

Proceedings Volume 3036, (1997) https://doi.org/10.1117/12.271300

KEYWORDS: Tissues, Signal detection, Electroluminescence, Speckle, Ultrasonography, Visualization, Breast, Finite element methods, Error analysis, Transducers

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