Prof. Paul L. Carson Profile

Prof. Paul L. Carson

Radiological Physicist Specializing in Ultrasound at Univ of Michigan Medical School

SPIE Involvement:

Author

Publications (37)

Proceedings Article | 13 March 2024 Presentation

Quantitative ionizing radiation acoustic imaging for radiation dose measurement: a phantom study validation

Yaocai Huang, Dale Litzenberg, Paul Carson, Issam El Naqa, Wei Zhang, Xueding Wang

Proceedings Volume PC12842, PC128420Y (2024) https://doi.org/10.1117/12.2691367

KEYWORDS: Ionizing radiation, Radiotherapy, Acoustics, Reconstruction algorithms, Image restoration, Tumors, Transducers, Tissues, Medical image reconstruction, Matrices

Read Abstract +

Proceedings Article | 13 March 2024 Presentation

Combined ionizing radiation acoustic and ultrasound dual-modality volumetric imaging for mapping the dose on anatomical structure during radiation therapy

Wei Zhang, Ibrahim Oraiqat, Yaocai Huang, Kaiwei Chang, Muhammad B. Alli, Dale Litzenberg, Scott Hadley, Christopher Tichacek, Eduardo Moros, Man Zhang, Paul Carson, Kyle Cuneo, Issam EI Naqa, Xueding Wang

Proceedings Volume PC12842, PC1284210 (2024) https://doi.org/10.1117/12.3000234

KEYWORDS: Radiotherapy, Anatomy, Biological imaging, Ultrasonography, Ionizing radiation, Acoustics, Imaging systems, Tissues, In vivo imaging, Visualization

Read Abstract +

Proceedings Article | 12 March 2024 Presentation + Paper

The development of ionizing radiation acoustic imaging (iRAI) for mapping the dose deep in the patient body during radiation therapy

Wei Zhang, Dale Litzenberg, Yaocai Huang, Kai-Wei Chang, Ibrahim Oraiqat, Scott Hadley, Eduardo Moros, Man Zhang, Paul Carson, Kyle Cuneo, Issam EI Naqa, Xueding Wang

Proceedings Volume 12842, 1284207 (2024) https://doi.org/10.1117/12.3000346

KEYWORDS: Radiotherapy, Ionizing radiation, Liver, Cancer, Acoustics, Imaging systems, Tumors, Real time imaging, Radiation oncology, Matrices

Read Abstract +

Proceedings Article | 9 March 2023 Presentation

Ionizing Radiation Acoustic Imaging (iRAI) for mapping the dose deep in the liver during radiation therapy

Wei Zhang, Ibrahim Oraiqat, Dale Litzenberg, Kai-Wei Chang, Scott Hadley, Noora Sunbul, Martha Matuszak, Christopher Tichacek, Eduardo Moros, Paul Carson, Kyle Cuneo, Xueding Wang, Issam El Naqa

Proceedings Volume PC12379, PC1237907 (2023) https://doi.org/10.1117/12.2647771

KEYWORDS: Radiotherapy, Liver, Acoustics, Ionizing radiation, 3D image processing, Visualization, Real time imaging, Imaging systems, Ultrasonography, Transducers

Read Abstract +

Proceedings Article | 7 March 2022 Presentation

Ionizing radiation acoustic imaging (iRAI) for volumetric dose mapping during external beam radiotherapy

Wei Zhang, Ibrahim Oraiqat, Kaiwei Chang, Noora Ba Sunbul, Dale Litzenberg, Kyle Cuneo, Paul Carson, Issam El Naqa, Xueding Wang

Proceedings Volume PC11960, PC1196015 (2022) https://doi.org/10.1117/12.2608005

KEYWORDS: Radiotherapy, Associative arrays, Real time imaging, Acoustics, Ionizing radiation, In vivo imaging, 3D modeling, Transducers, Tissues, Liver

Read Abstract +

Proceedings Article | 5 March 2021 Presentation + Paper

Spatially distributed sensor array calibration for photoacoustic imaging

Yuting Jiang, Yunhao Zhu, Xiang Ma, Hongchen Zhan, Chenglei Peng, Jie Yuan, Guan Xu, Xueding Wang, Paul Carson

Proceedings Volume 11642, 1164218 (2021) https://doi.org/10.1117/12.2576996

KEYWORDS: Sensors, Neuroimaging, Brain, Ultrasonography, Photoacoustic imaging, Calibration, Photoacoustic spectroscopy, Brain imaging, Sensor calibration, Transducers

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Ionizing radiation acoustic imaging (iRAI) for real-time monitoring of flash mode external beam radiotherapy

Wei Zhang, Ibrahim Oraiqat, Dale Litzenberg, Kwok Lam, Noora Ba Sunbul, Jean Moran, Kyle Cuneo, Paul Carson, Issam El Naqa, Xueding Wang

Proceedings Volume 11642, 116420V (2021) https://doi.org/10.1117/12.2576601

KEYWORDS: Radiotherapy, Ionizing radiation, Acoustics, Tissues, Real time imaging, Ultrasonography, Tumors, Liver, Imaging systems

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Ultrasound-mediated hyperthermia with the guidance of x-ray-induced radiation acoustic imaging

Kai-Wei Chang, Wei Zhang, Paul Carson, Issam El Naqa, Xueding Wang

Proceedings Volume 11642, 1164211 (2021) https://doi.org/10.1117/12.2576427

KEYWORDS: Ultrasonography, Acoustics, Transducers, Head, Real time imaging, Magnetic resonance imaging, X-rays, X-ray computed tomography, Tumors

Read Abstract +

Proceedings Article | 6 July 2018 Paper

Ultrasound transducer tracking system for correlation of masses in combined x-ray and manual breast ultrasound imaging

Qi You, Rungroj Jintamethasawat, Yuxin Wang, Jie Yuan, Marilyn Roubidoux, Ying Zhang, Paul Carson

Proceedings Volume 10718, 107181W (2018) https://doi.org/10.1117/12.2318115

KEYWORDS: Transducers, Ultrasonography, X-rays, Cameras, X-ray imaging, Breast, Calibration, Imaging systems, RGB color model, Digital breast tomosynthesis, Multimodal imaging, Biomedical ultrasonography, Ultrasonics, Ultrasound real time imaging, Ultrasound tomography

Read Abstract +

Proceedings Article | 13 March 2017 Presentation + Paper

Limited angle breast ultrasound tomography with a priori information and artifact removal

Rungroj Jintamethasawat, Yunhao Zhu, Oliver Kripfgans, Jie Yuan, Mitchell Goodsitt, Paul Carson

Proceedings Volume 10139, 101390N (2017) https://doi.org/10.1117/12.2253911

KEYWORDS: Ultrasonography, Ultrasound tomography, Tomography, Breast, Image segmentation, Breast cancer, Reconstruction algorithms, Tissues, Transducers, Image restoration

Read Abstract +

Proceedings Article | 3 March 2017 Paper

Comparison study on the feasibility of photoacoustic power spectrum analysis in osteoporosis detection

Weizhen He, Yunhao Zhu, Ting Feng, Huaideng Wang, Jie Yuan, Guan Xu, Xueding Wang, Paul Carson

Proceedings Volume 10064, 100645H (2017) https://doi.org/10.1117/12.2250677

KEYWORDS: Bone, Photoacoustic spectroscopy, Ultrasonography, Spectrum analysis, 3D modeling, Photoacoustic imaging, Numerical simulations, 3D image processing, Computed tomography, Minerals, Signal attenuation, Sensors, Tissues, Acoustics

Read Abstract +

Proceedings Article | 3 March 2017 Paper

Adipocyte property evaluation with photoacoustic spectrum analysis: a feasibility study on human tissues

Meng Cao, Yunhao Zhu, Robert O'Rourke, Huaideng Wang, Jie Yuan, Qian Cheng, Guan Xu, Xueding Wang, Paul Carson

Proceedings Volume 10064, 100645G (2017) https://doi.org/10.1117/12.2250674

KEYWORDS: Tissues, Spectrum analysis, Photoacoustic spectroscopy, Biopsy, Ultrasonography, Surgery, Tissue optics, Absorption, Statistical analysis, Biomedical optics

Read Abstract +

Proceedings Article | 31 October 2016 Paper

Adaptive photoacoustic imaging quality optimization with EMD and reconstruction

Chengwen Guo, Yao Ding, Jie Yuan, Guan Xu, Xueding Wang, Paul Carson

Proceedings Volume 10024, 100241S (2016) https://doi.org/10.1117/12.2244916

KEYWORDS: Biomedical optics, Photoacoustic tomography, Signal to noise ratio, Ultrasonography, Optimization (mathematics), Evolutionary algorithms, Reconstruction algorithms, Sensors, Algorithms, Signal processing

Read Abstract +

Proceedings Article | 1 April 2016 Paper

Automated 3D ultrasound image segmentation for assistant diagnosis of breast cancer

Yuxin Wang, Peng Gu, Won-Mean Lee, Marilyn Roubidoux, Sidan Du, Jie Yuan, Xueding Wang, Paul Carson

Proceedings Volume 9790, 979011 (2016) https://doi.org/10.1117/12.2203245

KEYWORDS: Image segmentation, Ultrasonography, Tissues, 3D image processing, Breast cancer, Breast, Diagnostics, Image analysis, Magnetic resonance imaging, Speckle, Signal to noise ratio, Visualization

Read Abstract +

Proceedings Article | 20 November 2014 Paper

Novel optimization method for multi-dimensional breast photoacoustic tomography

Meng Cao, Ting Feng, Jie Yuan, Sidan Du, Xiaojun Liu, Xueding Wang, Paul Carson

Proceedings Volume 9268, 92681H (2014) https://doi.org/10.1117/12.2070977

KEYWORDS: Acquisition tracking and pointing, Image quality, Breast, Biomedical optics, Transducers, Data acquisition, Ultrasonography, Tissue optics, Reconstruction algorithms, Photoacoustic tomography

Read Abstract +

Proceedings Article | 8 May 2014 Paper

Quantification of tissue texture with photoacoustic spectrum analysis

Xueding Wang, Guan Xu, Zhuo-Xian Meng, Jiandie Lin, Paul Carson

Proceedings Volume 9129, 91291L (2014) https://doi.org/10.1117/12.2051188

KEYWORDS: Liver, Tissues, Tissue optics, Photoacoustic spectroscopy, Spectrum analysis, Biomedical optics, Biopsy, Absorption, Medicine, Photoacoustic imaging

Read Abstract +

Proceedings Article | 4 March 2014 Paper

3D high resolution photoacoustic imaging based on pure optical photoacoustic microscopy with microring resonator

Zhixing Xie, Chao Tian, Sung-Liang Chen, Tao Ling, Cheng Zhang, L. Jay Guo, Paul Carson, Xueding Wang

Proceedings Volume 8943, 894314 (2014) https://doi.org/10.1117/12.2041010

KEYWORDS: Microrings, Resonators, Tissue optics, Image resolution, Photoacoustic microscopy, Optical microscopy, Sensors, 3D image processing, Photoacoustic spectroscopy, Signal detection

Read Abstract +

Proceedings Article | 3 March 2014 Paper

Functional pitch of a liver: fatty liver disease diagnosis with photoacoustic spectrum analysis

Guan Xu, Zhuoxian Meng, Jiandie Lin, Paul Carson, Xueding Wang

Proceedings Volume 8943, 89431G (2014) https://doi.org/10.1117/12.2037384

KEYWORDS: Liver, Tissues, Spectrum analysis, Absorption, Tissue optics, Blood, Photoacoustic spectroscopy, Pulsed laser operation, Imaging systems, Signal detection

Read Abstract +

Proceedings Article | 3 March 2014 Paper

A real-time photoacoustic and ultrasound dual-modality imaging system facilitated with GPU and code parallel optimization

Jie Yuan, Guan Xu, Yao Yu, Yu Zhou, Paul Carson, Xueding Wang, Xiaojun Liu

Proceedings Volume 8943, 894363 (2014) https://doi.org/10.1117/12.2038470

KEYWORDS: Imaging systems, Reconstruction algorithms, Acquisition tracking and pointing, Image restoration, Ultrasonography, Real time imaging, Photoacoustic spectroscopy, Tissue optics, Pulsed laser operation, Tissues

Read Abstract +

SPIE Journal Paper | 2 August 2013 Open Access

Real-time photoacoustic and ultrasound dual-modality imaging system facilitated with graphics processing unit and code parallel optimization

Jie Yuan, Guan Xu, Yao Yu, Yu Zhou, Paul Carson, Xueding Wang, Xiaojun Liu

JBO, Vol. 18, Issue 08, 086001, (August 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.8.086001

KEYWORDS: Imaging systems, Reconstruction algorithms, Acquisition tracking and pointing, Ultrasonography, Image restoration, Photoacoustic spectroscopy, Graphics processing units, Biomedical optics, Tissue optics, In vivo imaging

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 4 March 2013 Paper

High resolution photoacoustic imaging of microvasculature in normal and cancerous bladders

Zhixing Xie, William Roberts, Paul Carson, Xiaojun Liu, Chao Tao, Xueding Wang

Proceedings Volume 8581, 85810J (2013) https://doi.org/10.1117/12.2004482

KEYWORDS: Bladder, Tissues, Bladder cancer, Tumors, Cancer, Tissue optics, Image resolution, Photoacoustic imaging, 3D image processing, Signal detection

Read Abstract +

Proceedings Article | 4 March 2013 Paper

Combined photoacoustic and ultrasound imaging of human breast in vivo in the mammographic geometry

Zhixing Xie, Won-Mean Lee, Fong Ming Hooi, J. Brian Fowlkes, Renee Pinsky, Dean Mueller, Xueding Wang, Paul Carson

Proceedings Volume 8581, 85813D (2013) https://doi.org/10.1117/12.2004599

KEYWORDS: Breast, Ultrasonography, Imaging systems, Blood, 3D image processing, Tissues, Photoacoustic spectroscopy, 3D acquisition, Image compression, Mammography

Read Abstract +

Proceedings Article | 4 March 2013 Paper

Viewing individual cells and ambient microvasculature using two molecular contrasts

Zhixing Xie, Sung-Liang Chen, Mario Fabiilli, J. Brian Fowlkes, K. Kirk Shung, Qifa Zhou, Xunbin Wei, Paul Carson, Xueding Wang

Proceedings Volume 8581, 85813G (2013) https://doi.org/10.1117/12.2004666

KEYWORDS: Bladder, Luminescence, Imaging systems, Confocal microscopy, Signal detection, Photoacoustic spectroscopy, In vivo imaging, Absorption, Tumors, Microscopy

Read Abstract +

SPIE Journal Paper | 12 December 2012 Open Access

Photoacoustic and ultrasound dual-modality imaging of human peripheral joints

Guan Xu, Justin Rajian, Gandikota Girish, Mariana Kaplan, J. Brian Fowlkes, Paul Carson, Xueding Wang

JBO, Vol. 18, Issue 01, 010502, (December 2012) https://doi.org/10.1117/12.10.1117/1.JBO.18.1.010502

KEYWORDS: Imaging systems, Tissues, Ultrasonography, Acquisition tracking and pointing, Soft tissue optics, Tissue optics, Bone, Photoacoustic spectroscopy, Signal detection, Transducers

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 23 February 2012 Paper

Photoacoustic correlation spectroscopy for in vivo blood flow speed measurement

Sung-Liang Chen, Zhixing Xie, Paul Carson, Xueding Wang, L. Jay Guo

Proceedings Volume 8223, 82230O (2012) https://doi.org/10.1117/12.908442

KEYWORDS: Photoacoustic spectroscopy, Capillaries, Picture Archiving and Communication System, Blood, In vivo imaging, Blood circulation, Spectroscopy, Particles, Photoacoustic imaging, Imaging systems

Read Abstract +

Proceedings Article | 23 February 2012 Paper

3D high resolution pure optical photoacoustic microscopy

Zhixing Xie, Sung-Liang Chen, Tao Ling, L. Jay Guo, Paul Carson, Xueding Wang

Proceedings Volume 8223, 82230W (2012) https://doi.org/10.1117/12.906767

KEYWORDS: Microrings, Resonators, Tissue optics, Image resolution, Acoustics, Transducers, Sensors, Bladder, Photoacoustic spectroscopy, Waveguides

Read Abstract +

The concept of pure optical photoacoustic microscopy(POPAM) was proposed based on optical rastering of a focused excitation beam and optically sensing the photoacoustic signal using a microring resonator fabricated by a nanoimprinting technique. After some refinedment of in the resonator structure and mold fabrication, an ultrahigh Q factor of 3.0×105 was achieved which provided high sensitivity with a noise equivalent detectable pressure(NEDP) value of 29Pa. This NEDP is much lower than the hundreds of Pascals achieved with existing optical resonant structures such as etalons, fiber gratings and dielectric multilayer interference filters available for acoustic measurement. The featured high sensitivity allowed the microring resonator to detect the weak photoacoustic signals from micro- or submicroscale objects. The inherent superbroad bandwidth of the optical microring resonator combined with an optically focused scanning beam provided POPAM of high resolution in the axial as well as both lateral directions while the axial resolution of conventional photoacoustic microscopy (PAM) suffers from the limited bandwidth of PZT detectors. Furthermore, the broadband microring resonator showed similar sensitivity to that of our most sensitive PZT detector. The current POPAM system provides a lateral resolution of 5μm and an axial resolution of 8μm, comparable to that achieved by optical microscopy while presenting the unique contrast of optical absorption and functional information complementing other optical modalities. The 3D structure of microvasculature, including capillary networks, and even individual red blood cells have been discerned successfully in the proof-of-concept experiments on mouse bladders ex vivo and mouse ears in vivo. The potential of approximately GHz bandwidth of the microring resonator also might allow much higher resolution than shown here in microscopy of optical absorption and acoustic propagation properties at depths in unfrozen tissue specimens or thicker tissue sections not now imageable with current optical or acoustic microscopes of comparable resolution.

Proceedings Article | 23 February 2012 Paper

Drug delivery monitoring by photoacoustic tomography with an ICG encapsulated double emulsion

Xueding Wang, Justin Rajian, Mario Fabiilli, J. Brian Fowlkes, Paul Carson

Proceedings Volume 8223, 82232K (2012) https://doi.org/10.1117/12.906452

KEYWORDS: Photoacoustic spectroscopy, Plasma, Blood, Ultrasonography, Transducers, Absorption, Photoacoustic tomography, Proteins, Acoustics, Photoacoustic imaging

Read Abstract +

Proceedings Article | 11 April 2011 Paper

Photoacoustic imaging for deep targets in the breast using a multichannel 2D array transducer

Zhixing Xie, Xueding Wang, Richard Morris, Frederic Padilla, Gerald Lecarpentier, Paul Carson

Proceedings Volume 7899, 789907 (2011) https://doi.org/10.1117/12.875138

KEYWORDS: Breast, Imaging systems, Interference (communication), Tissues, Photoacoustic imaging, Transducers, 3D image processing, Photoacoustic spectroscopy, Ferroelectric polymers, Blood

Read Abstract +

Proceedings Article | 24 February 2010 Paper

A high-speed photoacoustic tomography system based on a commercial ultrasound and a custom transducer array

Xueding Wang, Jonathan Cannata, Derek DeBusschere, Changhong Hu, J. Brian Fowlkes, Paul Carson

Proceedings Volume 7564, 756424 (2010) https://doi.org/10.1117/12.842666

KEYWORDS: Ferroelectric polymers, Acquisition tracking and pointing, Imaging systems, Transducers, Ultrasonography, Signal detection, Photoacoustic spectroscopy, Photoacoustic imaging, Data acquisition, Tissues

Read Abstract +

Proceedings Article | 24 February 2010 Paper

Quantitative photoacoustic measurement of blood oxygen saturation in vivo aided by an optical contrast agent

Justin Rajesh Rajian, Paul Carson, J. Brian Fowlkes, Xueding Wang

Proceedings Volume 7564, 756412 (2010) https://doi.org/10.1117/12.842004

KEYWORDS: Photoacoustic spectroscopy, Tissues, Tissue optics, Blood, Absorption, Spectroscopy, Blood oxygen saturation, In vivo imaging, Oxygen, Blood vessels

Read Abstract +

Proceedings Article | 12 February 2009 Paper

Quantitative measurement of tissue optical absorption spectrum in a scattering medium by photoacoustic technique

Justin Rajesh Rajian, Paul Carson, Xueding Wang

Proceedings Volume 7177, 717715 (2009) https://doi.org/10.1117/12.809059

KEYWORDS: Tissue optics, Blood, Photoacoustic spectroscopy, Absorption, Spectroscopy, Scattering, Light scattering, Gold, Chromophores, Tissues

Read Abstract +

Proceedings Article | 12 February 2009 Paper

Reflection mode photoacoustic imaging through infant skull toward noninvasive imaging of neonatal brains

Xueding Wang, J. Brian Fowlkes, David Chamberland, Guohua Xi, Paul Carson

Proceedings Volume 7177, 717709 (2009) https://doi.org/10.1117/12.806651

KEYWORDS: Skull, Brain, Neuroimaging, Transducers, Photoacoustic spectroscopy, Ultrasonography, Photoacoustic imaging, Signal attenuation, Tissue optics, Tissues

Read Abstract +

Proceedings Article | 5 February 2008 Paper

Photoacoustic tomography of small-animal and human peripheral joints

Xueding Wang, David Chamberland, J. Brian Fowlkes, Paul Carson, David Jamadar

Proceedings Volume 6856, 685604 (2008) https://doi.org/10.1117/12.760811

KEYWORDS: Acquisition tracking and pointing, Tissue optics, Tissues, Transducers, Soft tissue optics, Photoacoustic tomography, Bone, Signal detection, Ultrasonography, Photoacoustic spectroscopy

Read Abstract +

Proceedings Article | 17 March 2007 Paper

Segmentation-free estimation of volume changes in 3D ultrasound of breast lesion phantoms

Ganesh Narayanasamy, R Narayanan, J. Brian Fowlkes, Marilyn Roubidoux, Paul Carson

Proceedings Volume 6510, 651033 (2007) https://doi.org/10.1117/12.711587

KEYWORDS: Tissues, Breast, Image registration, Tumors, Ultrasonography, Imaging systems, Data analysis, Image analysis, Image restoration, Motion estimation

Read Abstract +

Proceedings Article | 13 March 2007 Paper

Sub-pixel compounding from elasticity imaging data

Zhi Yang, Sumedha Sinha, Rebecca Booi, Marilyn Roubidoux, Bing Ma, J. Brian Fowlkes, Gerald LeCarpentier, Paul Carson

Proceedings Volume 6510, 651029 (2007) https://doi.org/10.1117/12.711649

KEYWORDS: Speckle, Image resolution, Ultrasonography, Image processing, Breast, Image compression, Image restoration, Image quality, Data acquisition, Image enhancement

Read Abstract +

Proceedings Article | 2 March 2006 Paper

High-speed large angle mammography tomosynthesis system

Jeffrey Eberhard, Paul Staudinger, Joe Smolenski, Jason Ding, Andrea Schmitz, Julie McCoy, Michael Rumsey, Abdulrahman Al-Khalidy, William Ross, Cynthia Landberg, Bernhard Claus, Paul Carson, Mitchell Goodsitt, Heang-Ping Chan, Marilyn Roubidoux, Jerry Thomas, Jacqueline Osland

Proceedings Volume 6142, 61420C (2006) https://doi.org/10.1117/12.653298

KEYWORDS: Ultrasonography, X-rays, Mammography, Breast, X-ray imaging, Sensors, Tomography, Ultrasonics, Reconstruction algorithms, Imaging systems

Read Abstract +

Proceedings Article | 24 June 1998 Paper

Computerized characterization of breast masses using three-dimensional ultrasound images

Berkman Sahiner, Gerald LeCarpentier, Heang-Ping Chan, Marilyn Roubidoux, Nicholas Petrick, Mitchell Goodsitt, S. Sanjay-Gopal, Paul Carson

Proceedings Volume 3338, (1998) https://doi.org/10.1117/12.310905

KEYWORDS: Ultrasonography, Breast, Feature extraction, 3D image processing, Image classification, Transducers, 3D acquisition, Image acquisition, Statistical analysis, Solids

Read Abstract +