Optical biosensors provide important opportunities and have broad application prospects in biomedicine, disease diagnosis, pharmaceutical, and other fields. In this paper, a reusable VCSEL (vertical cavity surface emitting laser) biosensor chip integrated with a multilayer nano grating structure is introduced. The selected laser wavelength is 850 nm, and the overall device adopts semiconductor laser packaging technology to achieve high integration of light source and multilayer nano grating. A small plasmonic biosensor platform based on hyperbolic metamaterial (HMMs) Au/Si3N4 is studied using the grating coupling principle. The transmission peak is adjusted to the wavelength of 850 nm by changing the nano grating parameters so as to improve the sensitivity of the sensor chip. However, the high cost of the sensor chip which is based on noble metal nanostructure and precision technology hinders its further application. In this paper, we propose to grow and remove parylene film on the sensor chip to realize the reuse of biosensors.
Infrared detectors are widely used in night vision imaging, security inspection, medical testing, environmental monitoring and other fields. Infrared detectors based on two-dimensional materials have become a research hotspot. A photoconductive graphene infrared detector based on inverted fluorination is introduced in this paper. An inverted fluorination method is adopted to reduce the physical bombardment damage to graphene and reduce the difficulty of graphene fluorination regulation. The Raman spectrum mapping of fluorinated graphene is analyzed. The variation of graphene Raman spectrum and infrared response against fluorination time is investigated, clarifying the properties of fluorinated graphene suitable for infrared sensing. The graphene sensor shows the highest responsivity when the value of ID/ID' peak ratio of the graphene Raman spectrum is the lowest. The photoconductive graphene infrared sensor based on controllable inverted fluorination process has the advantages of simple structure, high process feasibility.
Biosensors have broad application prospects in biomedicine, pharmacy, chemical industry and environmental monitoring. Therefore, the research and development of biosensors has become a new hotspot in the development of science and technology in the world. A vertical cavity surface emitting laser (VCSEL) biosensor chip integrated with gold nanostructures is introduced in this paper. The chip mainly uses the packaging technology of semiconductor laser to realize the high integration of light source, hexagonal gold nanoparticle array, and detection system. We use anodic aluminum oxide film (AAO) as a mask to prepare hexagonal gold nanoparticle array, combined with a microfluidic chip to realize the sensing application that can be sensitive to the change of environmental solution. We modify the gold nanoparticles on the chip surface with specific antibodies, and then inject different concentrations of protein solution for detection. The output light power changes with the change of environmental solution, so as to detect the concentration and type of biological solution. The sensor has the advantages of low cost, high sensitivity, and high integration.
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